脱发男士的福音：治疗脱发的药物有望两年内问世....

alqp6585030 · 发表于 2013-9-6 09:22:31

A hair lotion that cures baldness could be on the market within two years, believe scientists.

科学家相信，一种可以治疗脱发的洗头液将在两年内问世。

Scientists have found a single enzyme has a major role to play in male-pattern baldness, as experienced by the Duke of Cambridge. Photo: REX

科学家已经发现了一种导致男性脱发的蛋白酶，之前在剑桥公爵头上实验过了。

They are already talking with pharmaceutical firms about making the product, which would work by stopping the effects of a single guilty enzyme.

他们已经和制药企业谈论制作药物的事宜，只要阻止该蛋白酶发生作用，就可治疗脱发。

US-based dermatologists announced earlier this year that they had found that an enzyme, called prostaglandin D2 (PGD2), instructed follicles to stop producing hair.

位于美国的皮肤科医生早期宣布他们发现了该蛋白酶，叫做前列腺素D2(PGD2),它会阻止毛囊生出头发。

They identified it by screening 250 genes implicated in hair loss.

他们通过扫描250个跟脱发有关的基因找到了这种酶。

George Cotsarelis, head of dermatology at Pennsylvania University, said the one responsible for levels of PGD2 played “the major role”.

领导此研究的是宾夕法尼亚大学皮肤医学科教授乔治•柯萨莱利斯表示，影响前列腺素D2的水平的酶是造成脱发的元凶。

He said he was now talking with several drugs firms about creating the anti-baldness product.

他目前正与几家医药公司谈论生产脱发产品的事宜。

Drugs are already available that reduce PGD2 levels, as it has been implicated in asthma, holding out the hope that developing a related product for baldness could be speedy.

目前已经在治疗哮喘的药中发现降低前列腺素D2的水平的药物，这使得科学家认为开发出治疗脱发的产品指日可待。

About four in five men will experience some degree of baldness by the age of 70. In bald patches follicles are still making hairs, but less well than before. The hairs get shorter and shorter until they are either barely visible or do not even break the skin’s surface.

到了70岁，大约5个男士里就有4个会出现不同程度的秃头问题。脱发处的毛囊还会长出头发，但是比之前要稀很多。头发变得越来越少，直到几乎没有，或者就完全没有。

Cotsarelis and colleagues found that in 17 men with hair loss, PGD2 levels were three times higher in bald spots than in hairy areas.

柯萨莱利斯教授和他的同事研究17个脱发的男士，发现他们头上秃了的部分前列腺素D2的含量是有头发处的3倍。

When the original study was published in the journal Science Translational Medicine in March, he said: “We really do think if you remove the inhibition [caused by PGD2}, you get longer hair.”

当最初的研究发表在《科学转化医学》杂志上，他说：”我们真的冒出了切除抑制素，那么就能长出头发“的想法。

He said the finding raised the possibility of not only stopping hair loss, but of bald men also being able to regrow full heads of hair.

他说这一发现不仅增加了治疗脱发的可能性，而且对于秃头的男性也能重新长出浓密的头发。

Des Tobin, director of the centre for skin sciences at Bradford University, described the advance as “a big step forward”.

布拉德福德大学皮肤研究中心主任，Des Tobin，认为这一发现是”一个大进步“。

He said: “I can’t see why we won’t soon be able to intervene to prevent hair loss.”

他说：治疗脱发，指日可待。