英文高手请翻译下，谢谢

好难 · 发表于 2014-6-6 01:20:35

文章从国外ＢＢＳ抄来，回帖很高。请高手解释。

How Propecia works
Finasteride drops in both scalp and blood levels of DHT that causing hair loss. Finasteride 1-mg/day decreases serum DHT levels by almost 70%. Serum testosterone levels actually increased by 9%, but this is within the range of normal.
Using Propecia
During the first six months you may note some thinning of your existing hair. This may be due to either progression of your hair loss before finasteride has had a chance to work or some shedding of miniaturized hair that makes way for the new healthy anagen hair to grow. You should continue the medication for at least one year before you can assess its benefits.
Side Effects
Side effects from finasteride at the 1-mg dose are uncommon, but reversible. The five- year drug related side effects studied data showed that 4% of men taking finasteride 1mg experienced decreased libido, erectile dysfunction, and decreased volume of ejaculate.
Adverse Reactions
Adverse reactions related to the breast, including breast tenderness or breast enlargement (gynecomastia), occurred in 0.4% of men taking finasteride 1-mg (Propecia). Other reactions including rash, pruritus, urticarial (hives), swelling of the lips and face, and testicular pain.
Effects on PSA
Finasteride causes a decrease in serum PSA (prostate specific antigen) by approximately 50% in normal men. Since PSA levels are used to screen for prostate enlargement and prostate cancer, it is important that your personal physician is aware that you are taking Propecia (finasteride) so that he/she may take this into account when interpreting your PSA results.
Caution during Pregnancy
Women should not handle crushed or broken Propecia tablets when they are pregnant, or may potentially be pregnant. Exposure of pregnant women to semen from men treated with Propecia poses no risk to the fetus.
Long-Term Benefits and Risks
Results generally peak around one year and then are stable in the second year or decrease very slightly. Although the long-term ability of finasteride to maintain one’s hair is unknown, the majority of men find that after 5 years the medication is still working.
Increasing the Dose
There are published data demonstrating that 5 mg is no better than 1 mg from controlled clinical trials. In practice, often increase the dose when someone has been on the same dose of medication for about three years and then stops responding (begins to lose hair after being stable). When increasing the dose generally use generic finasteride 5mg, 1/3 pill a day.

Bombardier · 发表于 2014-6-6 02:51:36

1. 保法止（非那雄胺）如何作用
非那雄胺同时降低血液和头皮中的DHT浓度，减少脱发。一毫克的非那雄胺片可以降低血清中70%的DHT浓度。但血清中的睾酮浓度会升高9%，不过这是在正常范围内的。
2. 使用保法止
在前六个月内，你会观察到原生发变细。这是或许是因为你在使用保法止前，脱发问题正在加剧，或者是因为你细小的头发为了新生健康的头发腾地儿而掉落。在最终评估有效性以前，你应该持续使用保法止至少一年。
3. 副作用
一毫克的非那雄胺片对人体的副作用不多，但即使有也属可逆现象。一份5年的药物副作用研究显示，4%的男性感觉到他们的性欲降低，不举或硬度受到影响。
4. 不良反应
不良反应与胸部相关，0.4%的使用者感觉到胸部变大。其他的不良反应包括皮疹，皮肤瘙痒，荨麻疹等等皮肤问题。
5. 对前列腺特异抗原的作用
非那雄胺会降低血清中50%的前列腺特异抗原，正是因为非那雄胺经常被用于前列前增大和前列前癌的治疗，你应该在医生检查你的PSA指标前提醒他，你正在使用非那雄胺。
6. 孕妇注意事项
怀孕和可能怀孕的女性不要触摸破碎的保法止。怀孕的妇女接触到正在复用非那雄胺的男性的精液并不会对对胎儿造成影响。
7. 长期效果和风险
在使用保法止的第一年，效果会达到巅峰，随后在第二年保持稳定或轻微降低。尽管非那雄胺长期维持男性脱发情况的有效性还不确定，大量使用者发现他们使用五年非那雄胺后效果依然继续。
8. 增加药剂量
临床数据显示，5毫克非那雄胺并不会比1毫克非那雄胺更加有效。如果使用在在现有药剂量上持续三年或以上头发问题开始反弹，可以考虑增加药剂量。增加药剂量时，可以考虑每日使用三分之一5毫克的非那雄胺。

小弟不才，随便翻译了一下，希望能帮到你