|
|
转之前大概讲一下，懂这方面的人应该知道，柏林工业大学可以说非常牛叉，再加上德国人的性格，应该不会在这种比较严肃的问题上胡扯淡，由于我也不懂德语，所以还是从HAIRLOSSTALK上转过来吧（发该帖的人也是用GOOGLE翻译成英语的），由于翻译的问题，有很多地方不通顺，所以我就捡几个比较关键的信息说一下。
Here's an interview with Dr. Gerd Lindner, one of researchers that works with Dr. Roland Lauster at The Technical University of Berlin, the guys at the VERY TOP of the game for a hair loss cure. （以下是对Gerd Lindner博士的采访，他是柏林工业大学里Roland Lauster博士团队中的一员，他们这个团队在治疗脱发领域内非常权威）
We are pleased that Dr. Lindner would like to answer a few questions that are sure to see concrete against the background that many sufferers are urgently waiting a help with their hair loss problem.
问：There are a number of publications with different emphasis, however, is not easy to understand here the exact procedure. could you briefly describe the expiry of Haarfollikelzüchtung for your technology to us all:（请简短介绍一下你们的方法）
答：In our method, the Haarfollikelzüchtung is the world's first and only procedure in which autologous cells engineered to körpereigene- -so special "hair germs" are assembled.（我们的方法（叫作Haarfollikelzüchtung）是世界上第一个也是唯一一个针对人类的自体细胞移植工程，特别是针对头发胚芽的组装，（这里我翻译的不准确，因为有个德语我不认识））
First, while the subjects / patients are a few hair follicles taken from which the required cells are isolated. This will greatly multiplied, composed under special conditions again and covered with a biological matrix / protective layer so as to form inductive hair germs. This "Neopapillen" are small, hair-producing "Mikrofollikel" build already in a position in the culture dish. We have used this method just in a scientific journal ( Journal of Biotechnology described) in more detail.（更多具体的细节请参见这个期刊《Journal of Biotechnology described》）
We assume that this Mikrofollikel are also in the scalp able in the future to be able to produce a new hair.
问：It will therefore always be necessary to remove some hair, and then replace it in the desired shape?（这个过程是要去掉一些头发，然后用理想的形状来代替吗）
答：Yes, exactly (the small units producing our hair so) will be used as a FUE –Hair transplantation even with our method with small 0.9 mm biopsies hair follicles.However, depending on the degree of alopecia a much smaller number will have to be removed. Up to 30 biopsies are expected for 10000 hair germs must be taken, not even pinhead but are large. It's painless, leaves no visible scars and is done in a few minutes.（大意是用他们改进过的FUE技术进行上述过程，最关键的信息是只需提取30个活组织就可以培育出大约1万个头发的胚芽，这里一直不说毛囊而说胚芽估计是在医学上胚芽和毛囊不是同一个意思。这里我要详细说一下，现在的植发技术相当于从后枕部提取活组织然后种植到脱发区域，如果这一个活组织成活，那么就不会再掉发，否则还是掉。在医学上这个过程是在体外进行的，也就是说是在培养皿中进行活组织培育的，也可以说是克隆的，更通俗的讲就是制作人工毛囊。但之前最多只能培育出来2到3个成活的头发胚芽，所以价值并不高，但现在这个技术可以大量的培育出成活的头发胚芽，所以非常牛B）
问：What is the most difficult step in the process? （这个过程中最困难的步骤在哪）
答：The most difficult step is the preparation of the required cells, since this must be done under the microscope and it takes a lot of experience and especially for the coating with the biological matrix / protective layer. All other steps are indeed complex and expensive, because they must be performed in a clean room laboratories, but biotechnological standard. （最困难的步骤在于所需要的细胞的采集工作，因为这个过程必须在显微镜下完成，而且需要操作者有丰富经验，尤其是要用生物保护层去覆盖它。其他的步骤也很复杂，并且昂贵，因为所有的步骤都必须在生物技术标准意义下的实验室里才能进行）
问：How far are you? Does it work in animal models?（你们离成功还有多远，有在动物上实验过吗）
答：We have progressed so far with the development of this technology that preclinical animal studies and clinical trials on humans can be processed after acquisition of adequate financing in a detailed planned test program now. We are very confident that this technique is successful because at the development of hair shafts even succeed in vitro. In contrast to the human skin are here essential supporting factors such as nerve, support and blood supply does not exist yet does Mikrofollikelbildung.（一旦有了足够的财政支持我们就立刻开始对动物的临床前实验以及对人的临床试验，言下之意就是缺钱！但是我们非常自信我们会成功，因为巴拉巴拉）
问：Biotechnology is of course synonymous with progress on the one hand, for large safety concerns on the other side. How do you assess because from today's perspective, the safety of the procedure, a? （安全性上的考虑）
答：Security Studies Aderans (US) or Intercytex (GB) and other companies for the implantation of autologous cells in the scalp have promoted no identifiable risks to light in recent years. From our vantage point, therefore, our technology is safe, because the body's own material is used and this is not such as genetically modified. Finally, the reliability of the method is of course subject of clinical trials for our grafts under the enormous strict European ATMP (advanced therapy medicinal products) rules must be performed before a first application on the patient. If the trials are successful, the process has met the world's highest safety standards.（如果临床实验成功，那么这个过程的安全性就是国际上最高安全标准）
问：Let's talk about a very decisive question: You are working to make the procedure available to patients? And more importantly, how long will it take? （问一个决定性的问题：你觉得你们这个技术能在人类上应用吗，更重要的是，你们还要多久才能完成？）
答：Of Course is to provide objective of our development all this treatment option available. It will be gentler than any previous process and it may also cases can be treated at which lack sufficient donor hair currently there are no methods available. For our test program we need rigorous project management at about 5 years for all of the safety and efficacy of the grafts questions to clarify solid. In the course of the program, we treat in clinical trials already a significant number of those affected. An authorization may be achieved earlier than 5 years after the start, so far, however, we are still looking for partners for the necessary funding.（当然可以在人类上应用，然后巴拉巴拉一些好处，如果项目一旦开始，授权可以在五年内拿下。但是，我们还在寻找投资者以求必要的资金！）
问：Of course, it is much too early, but still a very important question: the procedure for a normal person will be affordable?（这个技术普通老百姓能负担的起吗？）
答：It is anticipated that the market price of admission is first is rather high. Years of development costs and the biotechnological production are the main price driver here. However, as well as the transplantation method comes in the mass application, the cost of the utilization of production facilities and the automation of manufacturing are likely to be significantly reduced.（可以预见，一开始市场价格会很高，但之后肯定会降下来。（就等于没说））
总结一下，借用HAIRLOSSTALK上某哥们的一句话（真是太对了）：NOBODY GIVES A SHIT ABOUT MENS BALDNESS.我觉得他们他们这个项目在寻找资金支持时可以面向全世界，聚沙也可以成塔嘛，不过考虑到商业的目的，估计他们也不会这么去做。不管怎样，大家还是应该乐观一点，尽管看起来挺遥远，但是至少有希望让你去等待，况且也不是渺茫到让你没有等待的必要。此外，我觉得目前比较好的一点就是无论德国，日本还是美国，现在已经有一些科学家开始专门研究脱发问题了，但愿这种竞争能更激烈一点，毕竟上亿人的市场在等待着他们。 |
|
脱发咨询
植发咨询
微信公众号
公众微信号haotoufa
老徐微博
发表于 2015-4-7 00:14:46
交流QQ群：86809880
收藏
支持
反对
楼主
